Using cutting-edge technology and microbiome science, NaturalRSO has identified proprietary strains, like Akkermansia muciniphila , that increase synthesis of health-promoting postbiotics and strengthen gut barrier integrity.
In a clinical trial , NaturalRSO’s flagship product NaturalRSO Glucose Control, a blend of Akkermansia muciniphila and four other high-potency bacterial strains, was shown to help lower A1C and post-meal glucose spikes in people with type 2 diabetes taking metformin.
Improving gut barrier function and maintaining healthy blood sugar levels with NaturalRSO’s clinically-studied strains, is a foundational way to help your patients find optimal health by harnessing the power of the gut microbiome.
Using cutting-edge technology and microbiome science, NaturalRSO has identified proprietary strains, like Akkermansia muciniphila , that increase synthesis of health-promoting postbiotics and strengthen gut barrier integrity.
In a clinical trial , NaturalRSO’s flagship product NaturalRSO Glucose Control, a blend of Akkermansia muciniphila and four other high-potency bacterial strains, was shown to help lower A1C and post-meal glucose spikes in people with type 2 diabetes taking metformin.
Improving gut barrier function and maintaining healthy blood sugar levels with NaturalRSO’s clinically-studied strains, is a foundational way to help your patients find optimal health by harnessing the power of the gut microbiome.
AKKERMANSIA MUCINIPHILA
The gut-lining builder
A highly targeted strain that can only be found in NaturalRSO Glucose Control & Akkermansia products. People with Type 2 diabetes are shown to be deficient in Akkermansia, which can be associated with healthy weight management.
CLOSTRIDIUM BUTYRICUM
The digestive health & butyrate-producer
Naturally found in the human GI tract, this strain is named for its ability to produce high amounts of the short-chain fatty acid butyrate. It has been associated with digestion support and immune health.
CLOSTRIDIUM BEIJERINCKII
The other butyrate producer
This novel strain produces the short-chain fatty acid butyrate, which helps the body process sugar and nourish the lining of the gut.
ANAEROBUTYRICUM HALLII
Another butyrate producer
Have we mentioned the importance of butyrate? This is another strain known to produce the short-chain fatty acid butyrate, helping the body process sugar and nourish the lining of the gut.
BIFIDOBACTERIUM INFANTIS
The digestive health booster
This heavy-hitter breaks down a range of foods and produces the intermediate molecules that are used by the three butyrate-producing strains we have. It also helps maintain a healthy GI tract and alleviates digestive issues.
CHICORY INULIN
The power source for our strains
A soluble fiber that can travel to the lower gut and feed our strains. We want to enhance our strains' abilities to perform their targeted functions.
AKKERMANSIA MUCINIPHILA
The gut-lining builder
A highly targeted strain that can only be found in NaturalRSO Glucose Control & Akkermansia products. People with Type 2 diabetes are shown to be deficient in Akkermansia, which can be associated with healthy weight management.
CLOSTRIDIUM BUTYRICUM
The digestive health & butyrate-producer
Naturally found in the human GI tract, this strain is named for its ability to produce high amounts of the short-chain fatty acid butyrate. It has been associated with digestion support and immune health.
CLOSTRIDIUM BEIJERINCKII
The other butyrate producer
This novel strain produces the short-chain fatty acid butyrate, which helps the body process sugar and nourish the lining of the gut.
ANAERO-BUTYRICUM HALLII
Another butyrate producer
Have we mentioned the importance of butyrate? This is another strain known to produce the short-chain fatty acid butyrate, helping the body process sugar and nourish the lining of the gut.
BIFIDO-BACTERIUM INFANTIS
The digestive health booster
This heavy-hitter breaks down a range of foods and produces the intermediate molecules that are used by the three butyrate-producing strains we have. It also helps maintain a healthy GI tract and alleviates digestive issues.
CHICORY INULIN
The power source for our strains
A soluble fiber that can travel to the lower gut and feed our strains. We want to enhance our strains' abilities to perform their targeted functions.
Synthesis of health-promoting postbiotics
NaturalRSO’s precise anaerobic strains restore the body’s natural capability to produce the postbiotic butyrate. Butyrate binds to specific receptors within the gut mucosa and stimulates the release of glucagon-like peptide-1 (GLP-1), which is an incretin hormone. GLP-1 is deficient in people with impared glucose tolerance and Type 2 diabetes, which contributes to hyperglycemia.
The benefits of GLP-1 go beyond diabetes. Balancing blood sugar is vital to health. In people not living with type 2 diabetes, GLP-1
Strengthen gut barrier and reduce permeability
Thinning in the large intestine mucin layer can lead to the development of gut dysbiosis, allowing pathogens and toxins to seep into systemic circulation. NaturalRSO probiotic formulations are uniquely able to improve the gut ecosystem and fuel fortification of the protective mucin layer, strengthening intestinal integrity.
The primary function of Akkermansia muciniphila, one of NaturalRSO’s proprietary strains, is to support healthy mucin layer turnover in the intestines, and thus strengthen the intestinal lining. Furthermore, this process releases short chain fatty acids such as acetate and propionate, that support the abundance and diversity of other health-promoting microorganisms in the gut.
Synthesis of health-promoting postbiotics
NaturalRSO’s precise anaerobic strains restore the body’s natural capability to produce the postbiotic butyrate. Butyrate binds to specific receptors within the gut mucosa and stimulates the release of glucagon-like peptide-1 (GLP-1), which is an incretin hormone. GLP-1 is deficient in people with impared glucose tolerance and Type 2 diabetes, which contributes to hyperglycemia.
The benefits of GLP-1 go beyond diabetes. Balancing blood sugar is vital to health. In people not living with type 2 diabetes, GLP-1
Strengthen gut barrier and reduce permeability
Thinning in the large intestine mucin layer can lead to the development of gut dysbiosis, allowing pathogens and toxins to seep into systemic circulation. NaturalRSO probiotic formulations are uniquely able to improve the gut ecosystem and fuel fortification of the protective mucin layer, strengthening intestinal integrity.
The primary function of Akkermansia muciniphila, one of NaturalRSO’s proprietary strains, is to support healthy mucin layer turnover in the intestines, and thus strengthen the intestinal lining. Furthermore, this process releases short chain fatty acids such as acetate and propionate, that support the abundance and diversity of other health-promoting microorganisms in the gut.
A1C REDUCTION
POST PRANDIAL GLUCOSE SPIKE REDUCTION
In a double-blind, placebo-controlled nutrition study, NaturalRSO Glucose Control was demonstrated to:
Clinical trial included participants taking metformin, compared to placebo.
1. Regarding the decreased A1C level, there was a reduction in mean A1C compared to placebo.
2. Observed reduction in glucose AUC is expected to increase time spent within the healthy glucose range (TIR70-180) during continuous glucose monitoring. Increases in TIR70-180 strongly correlate to reductions in A1C and reduced risk for complications in T2D.
We’ve partnered with top doctors, researchers, and scientists from pretty impressive institutions—like Stanford, Johns Hopkins, UCLA, Mayo Clinic, and the American Diabetes Association.
Our medical research team is led by Chief Medical Officer Orville Kolterman, MD. Dr. Kolterman is a diabetes expert and previous Chief Medical Officer at Amylin Pharmaceuticals, where he brought four diabetes drugs from early-stage development through trials to market.
Together with Dr. Kolterman, we work with leading diabetes professionals to ensure our products deliver results and meet the highest standards of efficacy and safety.
CHAIR, DIVISION OF ENDOCRINOLOGY
UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE
ASSOCIATE PROFESSOR, MEDICINE
MAYO CLINIC
NURSE PRACTITIONER
HENRY FORD HEALTH SYSTEM, CHAIR AMERICAN DIABETES ASSOCIATION (ADA) RESEARCH FOUNDATION
DIRECTOR, OPPENHEIMER CENTER FOR NEUROBIOLOGY OF STRESS AND RESILIENCE
PROFESSOR, DEPARTMENT OF MEDICINE
UCLA
CHIEF OF MEDICINE
MAYO CLINIC
DIRECTOR, CLINICAL DIABETES
UNIVERSITY OF SOUTHERN CALIFORNIA PRIVATE PRACTICE
CHIEF MEDICAL OFFICER
VIRTA HEALTH
FMR CHIEF SCIENTIFIC & MEDICAL OFFICER
AMERICAN DIABETES ASSOCIATION
PROFESSOR
UNIVERSITY OF WASHINGTON
PRACTITIONER
ROCKWOOD MULTICARE CENTER FOR DIABETES
ASSOCIATE PROFESSOR, INTEGRATIVE FUNCTIONAL GENOMICS, CLINICAL GENETICS AND SYNTHETIC BIOLOGY
CORNELL UNIVERSITY
CEO
SEMA4
DEAN PRECISION MEDICINE
MOUNT SINAI MEDICINE
PROFESSOR, CIVIL AND ENVIRONMENTAL ENGINEERING
STANFORD UNIVERSITY
ASSISTANT PROFESSOR, DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY
UCSF
CEO
NEUBASE THERAPEUTICS
CHAIR, DEPARTMENT OF HUMAN GENETICS
UNIVERSITY OF PITTSBURGH
CHAIR, DIVISION OF ENDOCRINOLOGY
UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE
ASSOCIATE PROFESSOR, MEDICINE
MAYO CLINIC
NURSE PRACTITIONER
HENRY FORD HEALTH SYSTEM, CHAIR AMERICAN DIABETES ASSOCIATION (ADA) RESEARCH FOUNDATION
DIRECTOR, OPPENHEIMER CENTER FOR NEUROBIOLOGY OF STRESS AND RESILIENCE
PROFESSOR, DEPARTMENT OF MEDICINE
UCLA
CHIEF OF MEDICINE
MAYO CLINIC
DIRECTOR, CLINICAL DIABETES
UNIVERSITY OF SOUTHERN CALIFORNIA PRIVATE PRACTICE
CHIEF MEDICAL OFFICER
VIRTA HEALTH
FMR CHIEF SCIENTIFIC & MEDICAL OFFICER
AMERICAN DIABETES ASSOCIATION
PROFESSOR
UNIVERSITY OF WASHINGTON
PRACTITIONER
ROCKWOOD MULTICARE CENTER FOR DIABETES
ASSOCIATE PROFESSOR, INTEGRATIVE FUNCTIONAL GENOMICS, CLINICAL GENETICS AND SYNTHETIC BIOLOGY
CORNELL UNIVERSITY
CEO
SEMA4
DEAN PRECISION MEDICINE
MOUNT SINAI MEDICINE
PROFESSOR, CIVIL AND ENVIRONMENTAL ENGINEERING
STANFORD UNIVERSITY
ASSISTANT PROFESSOR, DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY
UCSF
CEO
NEUBASE THERAPEUTICS
CHAIR, DEPARTMENT OF HUMAN GENETICS
UNIVERSITY OF PITTSBURGH
